WP 4

Partners

Efficiency / PK-PD

Goals

- Model phage PK/PD in in vitro/in vivo experimental data

- Develop mathematical models to optimize (combination/dose/regime)

- Evaluate efficiency in a rabbit model (biofilm, PPI)

Person in charge

Florent Valour, doctor

Acquisition of in vitro/in vivo/in biofilm phage dynamics data

PK/PD modeling and simulation on planktonic bacteria in vitro/in vivo

PK/PD modeling and activities of the biofilm formed in vivo

Evaluation of efficiency in two rabbit models (biofilm on material, prosthesis)

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Where to find us: Institute of Infectious Agents, Croix Rousse Hospital, 103 Grande rue de la Croix Rousse, 69004

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